Detalhe da pesquisa
1.
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Nature
; 586(7831): 735-740, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32879487
2.
Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS.
Circ Res
; 130(9): 1321-1341, 2022 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35382554
3.
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.
Brain
; 145(1): 324-339, 2022 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34264340
4.
AD-BERT: Using pre-trained language model to predict the progression from mild cognitive impairment to Alzheimer's disease.
J Biomed Inform
; 144: 104442, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37429512
5.
APP mouse models for Alzheimer's disease preclinical studies.
EMBO J
; 36(17): 2473-2487, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28768718
6.
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
PLoS Genet
; 13(8): e1006962, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28806762
7.
BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism.
J Neurosci
; 38(18): 4288-4300, 2018 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29632166
8.
ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
J Biol Chem
; 293(48): 18434-18443, 2018 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30315100
9.
HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via ß-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.
Am J Pathol
; 187(1): 91-109, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27993242
10.
Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease.
Neurobiol Learn Mem
; 154: 141-157, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29906573
11.
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
J Neurosci
; 35(16): 6544-53, 2015 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25904804
12.
Astrocytes from old Alzheimer's disease mice are impaired in Aß uptake and in neuroprotection.
Neurobiol Dis
; 96: 84-94, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27544484
13.
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aß generation in Alzheimer's disease.
Acta Neuropathol
; 132(2): 235-256, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26993139
14.
Inhibition of glycogen synthase kinase-3 ameliorates ß-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies.
J Biol Chem
; 288(2): 1295-306, 2013 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23155049
15.
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.
J Neurochem
; 130(1): 4-28, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24646365
16.
Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Am J Pathol
; 183(2): 369-81, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23747948
17.
Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer's disease and aging.
Nat Commun
; 15(1): 264, 2024 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38238311
18.
Cdk5 protein inhibition and Aß42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease.
J Biol Chem
; 287(10): 7224-35, 2012 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22223639
19.
ß-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
J Biol Chem
; 287(46): 38408-25, 2012 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22988240
20.
The Alzheimer's ß-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.
Acta Neuropathol
; 126(3): 329-52, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23820808